diff --git a/CMakeLists.txt b/CMakeLists.txt
index e3b60347d5..32defea756 100644
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -105,6 +105,7 @@ if(NOT PROFILER_ONLY)
         TARGETS "gfx900;gfx906;gfx908;gfx90a;gfx940;gfx941;gfx942;gfx1030;gfx1100;gfx1101;gfx1102")
 else()
     add_definitions(-DPROFILER_ONLY)
+    set(GPU_TARGETS "" CACHE STRING "" FORCE)
     if(GPU_TARGETS)
         message(FATAL_ERROR "For PROFILE_ONLY build, please do not set GPU_TARGETS, use GPU_ARCH = gfx9, gfx10, or gfx11")
     endif()
@@ -117,11 +118,12 @@ else()
     else()
         message(FATAL_ERROR "For PROFILE_ONLY build, please specify GPU_ARCH as gfx9, gfx10, or gfx11")
     endif()
+    set(GPU_TARGETS "${DEFAULT_GPU_TARGETS}" CACHE STRING " " FORCE)
 endif()
 
 message("Supported GPU_TARGETS= ${DEFAULT_GPU_TARGETS}")
 
-set(AMDGPU_TARGETS "${DEFAULT_GPU_TARGETS}" CACHE STRING " ")
+set(AMDGPU_TARGETS "${DEFAULT_GPU_TARGETS}" CACHE STRING " " FORCE)
 
 if(GPU_TARGETS)
     message("Building CK for the following targets: ${GPU_TARGETS}")