refactor: process isolation support for node replacement API

- Move REGISTERED_NODE_REPLACEMENTS global to NodeReplaceManager instance state
- Add NodeReplacement class to ComfyAPI_latest with async register() method
- Deprecate module-level register_node_replacement() function
- Call register_replacements() from comfy_entrypoint()

This enables pyisolate compatibility where extensions run in separate
processes and communicate via RPC. The async API allows registration
calls to cross process boundaries.

Refs: TDD-002
Amp-Thread-ID: https://ampcode.com/threads/T-019c2b33-ac55-76a9-9c6b-0246a8625f21

comfy_api/latest/__init__.py

@@ -22,6 +22,23 @@ class ComfyAPI_latest(ComfyAPIBase):
     VERSION = "latest"
     STABLE = False
 
+    class NodeReplacement(ProxiedSingleton):
+        async def register(self, node_replace: 'node_replace.NodeReplace') -> None:
+            """
+            Register a node replacement mapping.
+            
+            This async method supports process isolation via pyisolate, where
+            extensions run in separate processes. The call is RPC'd to the host
+            process where PromptServer and NodeReplaceManager live.
+            
+            Args:
+                node_replace: A NodeReplace object defining the old->new mapping
+            """
+            from server import PromptServer
+            PromptServer.instance.node_replace_manager.register(node_replace)
+
+    node_replacement: NodeReplacement
+
     class Execution(ProxiedSingleton):
         async def set_progress(
             self,

comfy_api/latest/_node_replace.py

@@ -1,13 +1,25 @@
 from __future__ import annotations
 
+import warnings
 from typing import Any
-import app.node_replace_manager
+
 
 def register_node_replacement(node_replace: NodeReplace):
     """
     Register node replacement.
+    
+    .. deprecated::
+        Use ``ComfyAPI.node_replacement.register()`` instead.
+        This synchronous function does not work with process isolation (pyisolate).
     """
-    app.node_replace_manager.register_node_replacement(node_replace)
+    warnings.warn(
+        "register_node_replacement() is deprecated. "
+        "Use 'await ComfyAPI.node_replacement.register()' instead for pyisolate compatibility.",
+        DeprecationWarning,
+        stacklevel=2
+    )
+    from server import PromptServer
+    PromptServer.instance.node_replace_manager.register(node_replace)
 
 
 class NodeReplace: