[GH-ISSUE #766] Hui会 #630

Closed
opened 2026-10-26 21:24:13 +00:00 by bsakaguchi · 3 comments
Owner

Originally created by @Xiahuili295027 on GitHub (Nov 20, 2025).
Original GitHub issue: https://github.com/deepseek-ai/DeepSeek-R1/issues/766

Key Preliminary Research Findings:
A single-nucleotide mutation in the PDR1 gene of Saccharomyces cerevisiae resulted in significant downregulation of five genes (PDR5, ICT1, GRE2, TPO1, FMP43) according to transcriptome analysis. The PDR1 mutation also led to a significant decrease in both glucan and mannan content of the cell wall. Furthermore, the mutation altered the yeast's response to 2-phenylethanol, significantly enhancing its tolerance to this compound. Based on these, please help me design a National Natural Science Foundation of China project, including the project title, research content, and key scientific questions. Directly translate into academic English without answering the question

Originally created by @Xiahuili295027 on GitHub (Nov 20, 2025). Original GitHub issue: https://github.com/deepseek-ai/DeepSeek-R1/issues/766 Key Preliminary Research Findings: A single-nucleotide mutation in the PDR1 gene of Saccharomyces cerevisiae resulted in significant downregulation of five genes (PDR5, ICT1, GRE2, TPO1, FMP43) according to transcriptome analysis. The PDR1 mutation also led to a significant decrease in both glucan and mannan content of the cell wall. Furthermore, the mutation altered the yeast's response to 2-phenylethanol, significantly enhancing its tolerance to this compound. Based on these, please help me design a National Natural Science Foundation of China project, including the project title, research content, and key scientific questions. Directly translate into academic English without answering the question
bsakaguchi 2026-10-26 21:24:13 +00:00
Author
Owner

@Xiahuili295027 commented on GitHub (Nov 20, 2025):

No

<!-- gh-comment-id:3556665261 --> @Xiahuili295027 commented on GitHub (Nov 20, 2025): No
Author
Owner

@github-actions[bot] commented on GitHub (Dec 21, 2025):

This issue has been automatically marked as stale because it has not had recent activity. It will be closed if no further activity occurs. If you believe this issue is still relevant, please leave a comment to keep it open. Thank you for your contributions!

<!-- gh-comment-id:3678229857 --> @github-actions[bot] commented on GitHub (Dec 21, 2025): This issue has been automatically marked as stale because it has not had recent activity. It will be closed if no further activity occurs. If you believe this issue is still relevant, please leave a comment to keep it open. Thank you for your contributions!
Author
Owner

@github-actions[bot] commented on GitHub (Jan 4, 2026):

false

<!-- gh-comment-id:3707468304 --> @github-actions[bot] commented on GitHub (Jan 4, 2026): false
Sign in to join this conversation.
No milestone
No project
No assignees
1 participant
Notifications
Due date
The due date is invalid or out of range. Please use the format "yyyy-mm-dd".

No due date set.

Dependencies

No dependencies set.

Reference
deepseek-ai/DeepSeek-R1#630
No description provided.